Lupus nephritis is a kidney caused by systemic lupus erythematosus involving an immune complex glomerulonephritis, systemic lupus erythematosus is a major cause of death and major complications. Systemic lupus erythematosus is one of the clinical manifestations of the symptoms of multiple system damage, chronic systemic autoimmune diseases, serum anti-nuclear antibody mainly having a number of different autoantibodies. The course of the disease in remission and is characterized by alternating episodes of acute, visceral (kidney, central nervous system) damage poor prognosis. The prevalence of the disease in our country 1000, higher than in Western countries reported 1/2000 common in women, especially women of childbearing age 20-40 years of age.
Systemic lupus erythematosus manifested as fatigue, weight loss, fever, rash, photosensitivity, vascular skin and other symptoms, lupus nephritis, usually subacute or chronic nephritis, damaged glomerular capillary plexus, the clinical manifestations nephrotic syndrome, hematuria, proteinuria, hypertension.
Lupus occurs when kidney damage known as lupus nephritis (LN). About 70% of SLE clinical manifestations of kidney damage. Lupus nephritis (LN) insidious onset may also be abrupt, the symptoms can be mild to severe. Symptoms of lupus nephritis involving nearly include glomerular and tubulointerstitial renal vascular damage series of symptoms, edema is common, 1/6 of patients with varying degrees of renal function decline at the time of diagnosis. Can be divided according to their clinical symptoms following types: (1) light: that asymptomatic hematuria and (or) proteinuria, this type accounted for 30% to 50%, more common clinical. Clinical manifestations of mild to moderate proteinuria and (or) hematuria, edema, hypertension, proteinuria and no less than 1g / d, with normal renal function. Pathology mostly mesangial proliferative or focal segmental lupus nephritis, the prognosis is good.
Acute nephritic syndrome type: rare, clinical manifestations such as acute post-streptococcal glomerulonephritis, acute onset there is a certain degree of hematuria, proteinuria, urinary tube. May have edema, hypertension, acute renal failure can occur even.
Rapidly progressive glomerulonephritis syndrome type: rare, clinically resembles rapidly progressive glomerulonephritis rapid onset, rapid development, oliguria or no urine, often hematuria, proteinuria, urinary tube, may have edema, often without only mild hypertension or high blood pressure, anemia and hypoalbuminemia. Rapid deterioration of renal function in the short term, a few weeks or months to the development of uremia. Pathological changes often severe diffuse proliferative, crescentic glomerulonephritis, or those with severe vasculitis.
Nephrotic syndrome: The most common accounting for about 60% of patients showed onset nephrotic syndrome. That massive proteinuria (> 3.5g / d), hypoalbuminemia, may have significant edema, but do not necessarily have elevated blood cholesterol. Lupus nephritis with nephrotic syndrome often have two cases, there is a simple expression of nephrotic syndrome, hematuria, no less, no or only mild hypertension, high blood pressure, slow the development of this type of disease, renal function in the long remained stable, mostly membrane pathology of lupus nephritis another addition to the symptoms of nephrotic syndrome, but with hematuria, hypertension and renal damage if not treated promptly, the majority can be developed to uremia in 2 to 3 years, pathology often diffuse proliferative lupus nephritis.
Chronic nephritic syndrome type: the performance of persistent proteinuria, hematuria, urinary tube and varying degrees of edema, hypertension, anemia and renal insufficiency. Longer duration, delayed healing of development to uremia. Pathology often diffuse proliferative lupus nephritis.
Tubules syndrome type: rare, manifested as chronic interstitial, tubular damage, there may be an increase in nocturia, lower specific gravity, hypertension, urinary enzymes increased, electrolyte acid-base balance disorders. More common in the distal renal tubular damage, there may be complete or incomplete renal tubular acidosis. This type is often associated with other types of combination.
To sum up our symptoms for lupus nephritis introduction, I am sure the symptoms of lupus nephritis have been understood that the life of lupus nephritis is more difficult to cure a disease, must be treated as soon as possible, we need to understand the etiology based on actively cooperate with medical treatment, maintain an optimistic attitude, and I believe that we will have some help cure the disease.
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