Why Do Proteinurine and Blood Urine Occur in FSGS

Focal segmental glomerulosclerosis, clinically more accustomed called FSGS, with minimal change nephritis and membranous nephritis, as both belong to an epithelial cell disease, the pathological changes of the epithelial cell disease are in clinical terms refractory nephrotic syndrome, renal biopsy done if the patient is already a focal segmental sclerosis, indicating the need for immediate treatment, the delay should not.

Why? We can see from the name, accompanied by renal biopsy results, the patient's kidneys had already started to harden up. Of course, now glomerular sclerosis also differs from sclerosing glomerulonephritis, its pathological lesions are focal segmental rather than diffuse, it shows that there is a cure. Just because the disease is associated with glomerular sclerosis, so compared to other diseases, some to be more serious. We also should know that the need for timely treatment of the disease, if not treated, it will gradually filled the air, eventually leading to the kidneys hardened, fibrosis.

Focal segmental glomerulosclerosis and membranous nephropathy clinical manifestations different, in addition to the clinical urine protein, it can also appear microscopic hematuria and hypertension. Usually such patients, urine protein and occult blood occur simultaneously, will be accompanied by the early onset of hypertension. At this point of the renin-dependent hypertension hypertension is mainly because a large part of this time of glomerular fibrosis has hardened or necrosis, and the rest have been impaired renal glomerular or will be in a ischemic state. In this kind of state, will cause the renin angiotensin aldosterone system activation, resulting in increased secretion of angiotensin. Of course, if the patient developed severe edema, then there will be capacity-dependent hypertension.

Explained by intrinsic cellular occurrence of urinary protein and blood in the urine

Focal segmental glomerulosclerosis vessel wall rupture exists because the disease caused by the epithelial cells of the early shedding of epithelial cells, basement membrane as the outermost layer, the pressure balance is disrupted, so that the basement membrane tissue adhesion together, if we find the basement membrane adhesions can cause local tissue damage, will appear after the rupture of vascular injury, and the emergence microscopic hematuria or gross hematuria, in addition, will have protein leakage.

Why did not the protein during treatment, and occult blood still exist?

Lesions in early clinical, and some patients have occult blood protein there, some only pure protein, some only pure occult blood, for both patients, we have to analyze the protein is from where, in the end what is cell damage why, in the course of treatment, and soon protein subsided, while occult blood but can not eliminate, we believe that case the protein is likely to be caused by occult blood.

Protein qualitative check of red blood cells rupture, hemoglobin released, and clinical indicators when hemoglobin tests, there will be positive for protein, so clinicians need at this time to explain to patients, the protein is likely to be occult blood appeared.

Capillary breakage, leakage of the blood components in the blood vessels into the cavity, the local will leak some cells to attract macrophages, inflammatory cells gather here, including some fibroblasts, fibroblasts and inflammation by necrotic tissue impact factor secreted extracellular matrix, resulting in partial hardening of fibrous tissue deposition in the local will eventually constitute focal segmental fibrosis.

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How to Treat Polycystic Kidney Disease (PKD) with Hematuria?

Hematuria means that red blood cells are in the urine. Urine does not normally contain red blood cells because the filters in the kidney prevent blood from entering the urine. In hematuria, the filters or other parts of the urinary tract allow blood to leak into the urine. Microscopic hematuria means that the blood is detected only with a microscope, while gross hematuria means the urine appears red or the color of tea or cola.Once hematuria appears, PKD patients are easy to have abdominal infections accompanied by fever, swelling and decrease in kidney function. Many PKD patients are eager to find the efficient and safe treatment.
With the enlargement of cysts, these cysts will oppress the kidney tissues and blood vessels in kidneys, which will cause microcirculation disturbance of kidney tissues. The kidneys will be in a state of hypoxic-ischemic, which will lead to the damage of capillary endothelial cell of kidneys. So blood in urine happens. As to those PKD patients with high blood pressure, the small blood vessels around cysts are easy to rupture.
These cysts may cause many symptoms and keep destroying the kidney function. In clinical, there are many cases that PKD develops into Renal Failure finally for the illness condition can not be controlled well. If wanting to eliminate hematuria, we should start with shrinking the cysts. Unfortunately, there are no efficient treatments for PKD patients in many countries, patients can only wait. When the illness condition turns into Renal Failure, the doctors will recommend you dialysis, after long-term dialysis, kidney transplant will be your last choice.
In addition to this therapy, the patients should keep a good mood and a healthy diet, which can make them recover as soon as possible.
Chinese herbs are recommended to treat hematuria caused by Polycystic Kidney Disease.

Chinese herbs can shrink the cysts by inactivating the epithelial cells and speeding up the blood circulation. Also, Chinese herbs can repair the damaged filtration membrane by dilating blood cells and clear the wastes accumulated in the membrane. Also, Chinese herbs will provide enough nutrition for the repair of kidney damage. In this way, hematuria will go away naturally.

Blood in Urine (Hematuria)

What is blood in urine (hematuria)?
Hematuria, or blood in the urine, can be either gross (visible) or microscopic (blood cells only visible through a microscope). Gross hematuria can vary widely in appearance, from light pink to deep red with clots. Although the amount of blood in the urine may be different, the types of conditions that can cause the problem are the same, and require the same kind of workup or evaluation.
What are the causes of blood in urine?
The causes of gross and microscopic hematuria are similar and may result from bleeding anywhere along the urinary tract. One cannot readily distinguish between blood originating in the kidneys, ureters (the tubes that transport urine from the kidneys to the bladder), bladder, or urethra. Any degree of blood in the urine should be fully evaluated by a physician, even if it resolves spontaneously.
Infection of the urine, (often called a urinary tract infection or UTI) stemming either from the kidneys or bladder, is a common cause of microscopic hematuria. Urine is naturally sterile and should not contain bacteria. Kidney and bladder stones can cause irritation and abrasion of the urinary tract, leading to microscopic or gross hematuria. Trauma affecting any of the components of the urinary tract or the prostate can lead to bloody urine. Hematuria can also be associated with renal (kidney) disease, as well as hematologic disorders involving the body's clotting system. Medications that increase the risk of bleeding, such as aspirin, warfarin (Coumadin), orclopidogrel (Plavix), may also lead to bloody urine. Lastly, cancer anywhere along the urinary tract can present with hematuria.
Treatment
Most teens don't need any kind of treatment for hematuria. When it's due to an infection, doctors might treat it with antibiotics. If hematuria is a sign of something more serious — like sickle cell disease — doctors will treat that condition.

If you've been treated for hematuria, your doctor will probably want you to get follow-up tests after treatment to make sure your urine is free of red blood cells. People who get blood in their urine more than once but have no other signs of illness may need urine tests and physical exams every few months for a year and yearly after that as a precautionary measure. If the hematuria goes away, your doctor may still want to check your urine once a year.