Creatinine is a waste product of muscle metabolism. When muscles work, they
break down proteins, including the amino acid creatine, to produce energy. Most
creatine is consumed but about 2 percent enters the bloodstream as creatinine.
The kidneys remove most creatinine. Levels of creatinine can be affected by age,
sex, race, diet, muscle mass, some medications, and chronic disease, such as
hyperthyroidism, hypothyroidism, diabetes and kidney disease. The normal range
of creatinine in blood serum is 0.75 to 1.3 mg/dL for men and 0.6 to 1.1 mg/dL
for women. Normal values may vary slightly depending on the laboratory and the
technique used.
The symptoms of kidney dysfunction differ broadly. A few people may have an
accidental finding of brutal kidney disease and high creatinine on routine blood
work without having any symptoms at all. For few others, depending on the cause
of problem, a lot of dissimilar symptoms may be present including:
Dehydrated sensation.
Fatigue
Shortness of breath.
Bewilderment or disoriented
Headache
Loss of appetite
Weight changes
Low-grade fever
A high level of creatinine is not a direct cause of symptoms, and someone
with above-normal levels may notice no change. Symptoms associated with high
creatinine are most often caused by an underlying illness that affects kidney
function. The most frequent cause is kidney disease itself. Symptoms of kidney
disease can include fatigue, headaches, loss of appetite, nausea or vomiting,
weight loss, itchy skin, swelling in the hands and feet, frequent or painful
urination or a change in the color of the urine.
Diabetes and high blood pressure are also associated with kidney failure.
Other symptoms may indicate muscle destruction, hypothyroidism, or diabetic
ketoacidosis as the cause of elevated creatinine. A high creatinine level does
not necessarily mean the person has chronic kidney disease, but indicates the
need for other tests.
没有评论:
发表评论