Why Do Proteinurine and Blood Urine Occur in FSGS

Focal segmental glomerulosclerosis, clinically more accustomed called FSGS, with minimal change nephritis and membranous nephritis, as both belong to an epithelial cell disease, the pathological changes of the epithelial cell disease are in clinical terms refractory nephrotic syndrome, renal biopsy done if the patient is already a focal segmental sclerosis, indicating the need for immediate treatment, the delay should not.

Why? We can see from the name, accompanied by renal biopsy results, the patient's kidneys had already started to harden up. Of course, now glomerular sclerosis also differs from sclerosing glomerulonephritis, its pathological lesions are focal segmental rather than diffuse, it shows that there is a cure. Just because the disease is associated with glomerular sclerosis, so compared to other diseases, some to be more serious. We also should know that the need for timely treatment of the disease, if not treated, it will gradually filled the air, eventually leading to the kidneys hardened, fibrosis.

Focal segmental glomerulosclerosis and membranous nephropathy clinical manifestations different, in addition to the clinical urine protein, it can also appear microscopic hematuria and hypertension. Usually such patients, urine protein and occult blood occur simultaneously, will be accompanied by the early onset of hypertension. At this point of the renin-dependent hypertension hypertension is mainly because a large part of this time of glomerular fibrosis has hardened or necrosis, and the rest have been impaired renal glomerular or will be in a ischemic state. In this kind of state, will cause the renin angiotensin aldosterone system activation, resulting in increased secretion of angiotensin. Of course, if the patient developed severe edema, then there will be capacity-dependent hypertension.

Explained by intrinsic cellular occurrence of urinary protein and blood in the urine

Focal segmental glomerulosclerosis vessel wall rupture exists because the disease caused by the epithelial cells of the early shedding of epithelial cells, basement membrane as the outermost layer, the pressure balance is disrupted, so that the basement membrane tissue adhesion together, if we find the basement membrane adhesions can cause local tissue damage, will appear after the rupture of vascular injury, and the emergence microscopic hematuria or gross hematuria, in addition, will have protein leakage.

Why did not the protein during treatment, and occult blood still exist?

Lesions in early clinical, and some patients have occult blood protein there, some only pure protein, some only pure occult blood, for both patients, we have to analyze the protein is from where, in the end what is cell damage why, in the course of treatment, and soon protein subsided, while occult blood but can not eliminate, we believe that case the protein is likely to be caused by occult blood.

Protein qualitative check of red blood cells rupture, hemoglobin released, and clinical indicators when hemoglobin tests, there will be positive for protein, so clinicians need at this time to explain to patients, the protein is likely to be occult blood appeared.

Capillary breakage, leakage of the blood components in the blood vessels into the cavity, the local will leak some cells to attract macrophages, inflammatory cells gather here, including some fibroblasts, fibroblasts and inflammation by necrotic tissue impact factor secreted extracellular matrix, resulting in partial hardening of fibrous tissue deposition in the local will eventually constitute focal segmental fibrosis.

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