Focal glomerulosclerosis stage which is divided into several types

Focal glomerulosclerosis (focal glomeruloscerosis) refers to the glomerular capillary loops focal segmental sclerosis or hyaline degeneration, no significant proliferation of a type of glomerular capillaries. As mesangial proliferation, mesangial IgM deposition and focal glomerulosclerosis, but minimal change nephropathy steroid-resistant, recurrent and chronic consequences of progress. Hormone also ineffective early biopsy is the primary nephrotic syndrome with focal glomerulosclerosis. Therefore, whether the disease as an independent glomerular disease is still controversial. However, other kidney disease represents a different clinical pathology, but also as an independent disease, more common, and there is a growing trend.

FSGS may be idiopathic, but also for many different end-stage disease common morphological features the so-called "different way Tonggui."

Depending on the different pathogenesis and disease progression, from a morphological analysis can be divided into four types:

① peripheral type: glomerular surrounding sclerosis, hardened area often associated with parietal epithelial cell adhesion, common in children with idiopathic FSGS this type;

② Mixed: glomerular sclerosis umbilical very transparent with vascular degeneration, vascular lesions began pole, adult idiopathic FSGS common of this type;

③ collapse types: open loop glomerular bad, shrinkage, capillary loops widespread collapse, this type of multi associated with viral infection;

④ nodular type: mesangial matrix increase, the formation of nodules, often accompanied by afferent artery hyaline degeneration, diabetic nephropathy typical morphological changes.

The disease can occur at any age, youth-oriented. More common in men. Showed persistent non-selective proteinuria. Typical cases mostly onset nephrotic syndrome, accounting for about 50 percent, accounting for primary nephrotic syndrome 5% to 20%. 50% to 60% of patients with hematuria. Hypertension and renal damage reports varies from 10% to 50%, and clinical manifestations of urinary protein level, especially with prognosis.

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